| Accession NO. | GSE30153 |
|---|---|
| Cell Count | |
| Technique | |
| PMID | 21886837 |
| Title | B cell signature during inactive systemic lupus |
| Organism | Homo sapiens |
| Overall design | 17 patients with quiescent lupus (patient1-17) versus 9 controls (Control1-6,Control8-10). |
| Summary | Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. In order to approach these defects in humans, we compared the peripheral B cell transcriptomes of quiescent lupus patients to normal B cell transcriptomes. |
A spatial transcription database site for diseases of human systems
