Accession NO. | GSE48134 |
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Cell Count | |
Technique | |
PMID | 24821806 |
Title | Designed Oligooxopiperazines as Modulators of Hypoxia-Inducible Factor Signaling |
Organism | Homo sapiens |
Overall design | Hypoxic A549 cells were treated with transcriptional inhibitors BB2-162, BB2-125, BB2-282 or vehicle and their expression profiles were compared to normoxic A549 cells treated with vehicle. |
Summary | We performed gene expression profiling of oligooxopiperazines (OPs) targeting the hypoxia-inducible transcription factor complex. Treatment of cells with OPs inhibited hypoxia-inducible gene expression in A549 cells. |