| Accession NO. | GSE201772 |
|---|---|
| Cell Count | |
| Technique | |
| PMID | 35983043 |
| Title | Dynamically Upregulated Mast Cell CPA3 Patterns in lung disease |
| Organism | Homo sapiens |
| Overall design | Comparing primary human mast cells from healthy donors |
| Summary | The mast cell-specific metalloprotease CPA3 has been given important roles in lung tissue homeostasis and disease pathogenesis. However, the dynamics and spatial distribution of mast cells CPA3 expression in lung diseases remains unknown. Methods: Using a histology-based approach for spatial and quantitative simultaneous decoding of mRNA and protein expression at a single cell level, this study investigates the dynamics of CPA3 expression across mast cells residing in lungs from healthy controls and patients with severe chronic obstructive pulmonary disease (COPD) or idiopathic lung fibrosis (IPF). Results: Mast cells in COPD lungs had increased CPA3 mRNA bations in COPD and IPF-affected lungs have spatially complex and markedly up-regulated CPA3 expression profiles that correlates with sites of structural pathologies. Given the proposed roles of CPA3 in tissue homeostasis, remodeling and inflammation, these alterations are likely to have clinical consequences. |
A spatial transcription database site for diseases of human systems
